In people regarding mild renal impairment (baseline creatinine clearance = 30 to 50 mL/min), a dosage decrease to 75 % of the provigil beginning dose when made use of as monotherapy or in combo regarding docetaxel (from 1250 mg/m2 to 950 mg/m2 two times daily) is recommended [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)] Succeeding dosage modification is recommended as outlined in Table 2 as well as Table 3 (depending upon the routine) if an individual creates a quality 2 to 4 negative event [ see Warnings and Precautions (5.5)] The beginning dosage modification referrals for people with moderate renal problems use to both provigil monotherapy and provigil in mix usage with docetaxel.

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In this study, 4.8 % of patients aged 75 years as well as older stopped modafinil therapy due to renal dysfunction vs.